Download MendeleyThe structure of 1NA in complex with Src T338G
Eck, M.J., Yun, C.H.To be published.
4K11
The structure of 1NA in complex with Src T338G
- PDB DOI: https://doi.org/10.2210/pdb4K11/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Spodoptera frugiperda
- Mutation(s): Yes
- Deposited: 2013-04-04 Released: 2014-04-09
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.30 ?
- R-Value Free: 0.246
- R-Value Work: 0.196
- R-Value Observed: 0.199
Starting Model: experimental
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This is version 1.5 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Proto-oncogene tyrosine-protein kinase Src | 448 | Homo sapiens | Mutation(s): 1 Gene Names: SRC, SRC1 EC: 2.7.10.2 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P12931 (Homo sapiens) Explore P12931 Go to UniProtKB: P12931 | |||||
PHAROS: P12931 GTEx: ENSG00000197122 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P12931 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| 0J9 Query on 0J9 | B [auth A] | 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine C19 H19 N5 XSHQBIXMLULFEV-UHFFFAOYSA-N |  | ||
| Modified Residues 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Type | Formula | 2D Diagram | Parent |
| PTR Query on PTR | A | L-PEPTIDE LINKING | C9 H12 N O6 P |  | TYR |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.30 ?
- R-Value Free: 0.246
- R-Value Work: 0.196
- R-Value Observed: 0.199
- Space Group: P 21 21 21
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 50.96 | ¦Á = 90 |
| b = 72.72 | ¦Â = 90 |
| c = 171.98 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| CNS | refinement |
| MAR345 | data collection |
| DENZO | data reduction |
| SCALEPACK | data scaling |
| CNS | phasing |
Entry History
Revision History (Full details and data files)
- Version 1.0: 2014-04-09
Type: Initial release - Version 1.1: 2017-11-15
Changes: Refinement description - Version 1.2: 2019-07-17
Changes: Data collection, Derived calculations, Refinement description - Version 1.3: 2023-09-20
Changes: Data collection, Database references, Derived calculations, Refinement description - Version 1.4: 2023-12-06
Changes: Data collection - Version 1.5: 2024-11-20
Changes: Structure summary
